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関連する概念動画

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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関連する実験動画

Updated: Jun 17, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

エピジェネティック療法への切り替え

Sascha Karberg

    Cell
    |December 17, 2009
    PubMed
    まとめ

    エピミュテーションとして知られる可逆的な表遺伝子変化は,様々な疾患の特徴です. バイオテクノロジー企業は,遺伝子発現におけるこれらの病原性変化を修正するための新しい治療法を開発しています.

    科学分野:

    • 分子生物学は分子生物学である.
    • 遺伝学 遺伝学とは
    • エピジェネティクス エピジェネティクス

    背景:

    • DNAメチル化やヒストンの変異などのエピジェネティック変異は,遺伝子発現の調節に重要な役割を果たします.
    • エピミュテーションと呼ばれる異常な表遺伝子変化は,がんを含む様々な疾患の発達と進行に大きく寄与する要因としてますます認識されています.
    • これらのエピミュテーションは潜在的に可逆性があり,治療の機会を提供します.

    研究 の 目的:

    • 病気の病原性における可逆性表观遺伝子の変化の役割を強調する.
    • エピミュテーションをターゲットとした新興の治療戦略を強調する.

    主な方法:

    • エピジェネティクスと病気に関する現在の科学文献のレビュー.
    • バイオテクノロジーにおける薬物開発の動向の分析は,表遺伝的標的に焦点を当てた.

    主要な成果:

    • エピジェネティック不調は,人間の疾患のスペクトル全体に共通する特徴です.
    • バイオテクノロジー企業は,病原性のエピミュテーションを逆転させるための薬剤に積極的に投資し,開発しています.
    • これらの新薬は,表遺伝的メカニズムをターゲットにすることで,正常な遺伝子発現パターンを回復することを目的としています.

    さらに関連する動画

    In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
    10:44

    In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

    Published on: May 5, 2023

    Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins
    09:56

    Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins

    Published on: October 31, 2025

    関連する実験動画

    Last Updated: Jun 17, 2026

    Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
    10:28

    Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

    Published on: September 20, 2018

    In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
    10:44

    In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

    Published on: May 5, 2023

    Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins
    09:56

    Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins

    Published on: October 31, 2025

    結論:

    • リバーシブルな表遺伝子改変は,研究と治療開発の重要な分野です.
    • エピミュテーションをターゲットにすることで,遺伝子発現が変化した病気の治療が期待されます.