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Structure of Cadherins01:25

Structure of Cadherins

4.0K
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
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Mechanism of Conjugation01:19

Mechanism of Conjugation

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Bacterial conjugation is a mechanism of horizontal gene transfer that enables the exchange of genetic material between bacterial cells through direct contact. This process is facilitated by a donor cell carrying a conjugative plasmid, which encodes genes necessary for pilus formation, DNA replication, and transfer. The conjugative plasmid plays a central role in initiating and executing the transfer of genetic material.The tra region of the conjugative plasmid encodes proteins responsible for...
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Prescribed 3-D Direct Writing of Suspended Micron/Sub-micron Scale Fiber Structures via a Robotic Dispensing System
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多サブユニット連結複合体DSL1による膀捕獲のための構造ベースのメカニズム.

Yi Ren1, Calvin K Yip, Arati Tripathi

  • 1Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Cell
|December 17, 2009
PubMed
まとめ

Dsl1複合体は,最も単純な結合装置で,輸送のために膀を捕獲します. その構造は,それがSNAREタンパク質に結合し,膀融合と交通をオーケストラ化する方法を明らかにします.

科学分野:

  • 細胞生物学 細胞生物学
  • 分子生物学と構造生物学について

背景:

  • 膀の密輸は,SNAREタンパク質によって駆動される膜融合に依存しています.
  • テザリング・コンプレックス (MTC) は,最初の膀と標的の臓器の結合を媒介する.
  • Dsl1複合体は,最も単純なMTCであり,ゴルギからERへの逆行COPIベシクル輸送に不可欠です.

研究 の 目的:

  • Dsl1複合体の構造を決定する.
  • 膀結合と融合におけるMTC機能の構造的基礎を理解する.

主な方法:

  • Dsl1複合体の構造を決定するX線結晶学.

主要な成果:

  • Dsl1複合体は塔のような構造で,底部にはSNARE結合部位があり,先端には膀を捕捉するラッソがあります.
  • 複合体は,個々のSNAREと組み立てられたSNARE複合体の両方を結合します.
  • Dsl1はSNARE複合体の組み立てを加速する.

結論:

  • Dsl1複合体の構造は,膀の捕獲,SNARE結合,そして潜在的にSNARE複合体の組み立てを容易にする.
  • 単純なMTCでさえ,捕獲,脱コーティング,融合を含む,膀の密輸の複数のステップをオーケストラすることができます.

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