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Updated: Jun 17, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
11:02

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

Published on: October 18, 2013

ヒトがんゲノムからの体変異の包括的なカタログ

Erin D Pleasance1, R Keira Cheetham, Philip J Stephens

  • 1Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

Nature
|December 18, 2009
PubMed
まとめ

この研究は,個々の悪性メラノーマの体内変異をカタログ化し,紫外線を支配的な変異シグネチャーとして明らかにしています. 転写された領域における好ましいDNA修復を強調し,がんゲノム進化の洞察を提供している.

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