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Updated: Jun 17, 2026

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
09:17

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions

Published on: August 2, 2018

低酸素誘導性因子1トランスクリプションコアクティベーターの相互作用を,水素結合代理アルファ-ヘリックスによって阻害する

Laura K Henchey1, Swati Kushal, Ramin Dubey

  • 1Department of Chemistry, New York University, New York, New York 10003, USA.

Journal of the American Chemical Society
|January 1, 2010
PubMed
まとめ

研究者は合成アルファヘリクスを設計し,低酸素誘導性遺伝子発現を抑制しました. この分子は,重要なタンパク質の相互作用を妨害し,VEGFやGLUT1のような遺伝子をダウンレギュレーションし,がん研究と薬剤発見の可能性を秘めています.

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