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Updated: Jun 17, 2026

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
15:23

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

Published on: May 13, 2010

強力で選択的なトランスチレチン運動安定剤を作り,アミロイドゲネシスと細胞毒性を防止するサブストラクチャの組み合わせ戦略

Sungwook Choi1, Natàlia Reixach, Stephen Connelly

  • 1Department of Chemistry, The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|January 2, 2010
PubMed
まとめ

研究者らは,TTR集積および関連するアミロイド疾患を予防するために,新しいトランスチレチン (TTR) 運動安定剤を開発しました. これらの化合物はTTRを安定させ,神経変異を止め,細胞を細胞毒性作用から救う.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...