Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

17.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
17.8K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

2.0K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
2.0K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

2.9K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.9K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

9.1K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
9.1K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

9.8K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.8K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

CD52 and OXPHOS-potential targets in ibrutinib-treated mantle cell lymphoma.

Cell death discovery·2022
Same author

First-line Treatment With Bendamustine and Rituximab for Old and Frail Patients With Aggressive Lymphoma: Results of the B-R-ENDA Trial.

HemaSphere·2022
Same author

MYC multimers shield stalled replication forks from RNA polymerase.

Nature·2022
Same author

Panel Sequencing of Primary Cutaneous B-Cell Lymphoma.

Cancers·2022
Same author

Vitamin D Receptor Expression Is Significantly Decreased in Bone Metastases Compared to Matched Primary Breast Cancer Tumours.

Cancer investigation·2022
Same author

Identification of Disparities in Personalized Cancer Care-A Joint Approach of the German WERA Consortium.

Cancers·2022

関連する実験動画

Updated: Mar 13, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

12.6K

慢性的に活発なB細胞受容体シグナル伝達が,拡散型大B細胞リンパ腫で起きている.

R Eric Davis1, Vu N Ngo, Georg Lenz

  • 1Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Nature
|January 8, 2010
PubMed
まとめ

慢性的に活発なB細胞受容体 (BCR) 信号伝達は,活性化されたB細胞のような拡散型大B細胞リンパ腫 (ABC DLBCL) の生存率を左右する. CD79BのようなBCR成分における突然変異は,このリンパ腫亜型における新たな腫瘍発生機構を明らかにする.

さらに関連する動画

A BW Reporter System for Studying Receptor-Ligand Interactions
06:05

A BW Reporter System for Studying Receptor-Ligand Interactions

Published on: January 7, 2019

8.2K
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

22.6K

関連する実験動画

Last Updated: Mar 13, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

12.6K
A BW Reporter System for Studying Receptor-Ligand Interactions
06:05

A BW Reporter System for Studying Receptor-Ligand Interactions

Published on: January 7, 2019

8.2K
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

22.6K

科学分野:

  • 腫瘍学 腫瘍学
  • 免疫学 免疫学とは
  • 分子生物学は分子生物学である.

背景:

  • 人間のリンパ腫におけるB細胞受容体 (BCR) 信号伝達の腫瘍学的役割については,さらなる遺伝的および機能的検証が必要である.
  • 活性化されたB細胞型 (ABC) 拡散型大B細胞リンパ腫 (DLBCL) は,生存のために特定のシグナル伝達経路に依存しています.

研究 の 目的:

  • ABC DLBCL生存における慢性的な活性BCR信号伝達のメカニズムを調査する.
  • ABC DLBCLの病原性にとって重要な遺伝子変異とシグナル伝達成分を特定する.

主な方法:

  • 生存に必要な遺伝子を特定するためのRNA干渉遺伝子スクリーニング.
  • リンパ腫のサンプルにおけるBCRのクラスタリング,拡散,および体内の変異の分析.
  • 変異がBCR発現とリンキナーゼ活性に与える影響を調査する.

主要な成果:

  • 慢性的に活発なBCRシグナリングは,ABC DLBCLの生存に不可欠であり,特に野生型のCARD11の症例では特に重要です.
  • ブルートンのチロシンキナーゼと近隣BCRサブユニット (CD79A,CD79B) は生存に不可欠です.
  • CD79AとCD79BのITAMモチーフの体内変異は,ABC DLBCLで頻繁に発見され,BCR信号調節に影響を与えました.

結論:

  • 慢性的な活性BCRシグナル伝達は,ABC DLBCLにおける新たな病原遺伝的メカニズムを表しています.
  • CD79BおよびCD79AITAMの変異は,BCRシグナル伝達を調節し損なうことでリンパ生成に寄与する.
  • これらの発見は,ABC DLBCLにおけるBCRシグナリングを標的とした潜在的な治療戦略を示唆しています.