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慢性的に活発なB細胞受容体シグナル伝達が,拡散型大B細胞リンパ腫で起きている

R Eric Davis1, Vu N Ngo, Georg Lenz

  • 1Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Nature
|January 8, 2010
PubMed
まとめ

慢性的に活発なB細胞受容体 (BCR) 信号伝達は,活性化されたB細胞のような拡散型大B細胞リンパ腫 (ABC DLBCL) の生存率を左右する. CD79BのようなBCR成分における突然変異は,このリンパ腫亜型における新たな腫瘍発生機構を明らかにする.

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