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関連する概念動画

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

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腫瘍は,循環するがん細胞によって自己増殖する.

Mi-Young Kim1, Thordur Oskarsson, Swarnali Acharyya

  • 1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Cell
|January 13, 2010
PubMed
まとめ

癌細胞は元の腫瘍に戻り,この過程は腫瘍の自己増殖と呼ばれます. この攻撃的な循環腫瘍細胞 (CTC) の行動は,がんの成長を加速し,手術後の局所的な再発を説明する可能性があります.

科学分野:

  • 腫瘍学 腫瘍学
  • がん生物学 がん生物学
  • メタスタシス研究

背景:

  • 転移は,伝統的に,がん細胞が原発腫瘍から遠隔部位に片方向に広がったものと見なされている.
  • 拡散後の循環腫瘍細胞 (CTC) の運命と行動は完全に理解されていません.

研究 の 目的:

  • 循環腫瘍細胞 (CTC) が,その原発腫瘍をコロニー化する可能性を調査する.
  • 臨床前がんモデルにおけるこの"腫瘍の自己播種"プロセスのメカニズムと結果を特定する.

主な方法:

  • 乳がん,結腸がん,メラノーマのマウスモデルを使用した.
  • CTC浸透における特定のサイトカイン (IL-6,IL-8),酵素 (MMP1/コラーゲネーゼ-1),および細胞骨格成分 (ファシン-1) の役割を分析した.
  • 腫瘍の成長,血管新生,およびストロマ細胞の徴募に対する自己種子の影響を調査し,CXCL1.1のような要因を調べました.

主要な成果:

  • 骨,肺,または脳の転移性トロピズムを持つものを含む攻撃的なCTCは,その主要な腫瘍 (腫瘍の自己種) を植民地化することが可能であることを実証した.
  • CTCの主要なアトラクタとしてIL-6とIL-8を特定し,乳腺腫瘍への浸透の媒介者としてMMP1/コラーゲネーゼ-1とファスニン-1を特定した.
  • セルフシードが部分的にCXCL1.1経由で腫瘍の成長,血管新生,およびストロマの徴募を加速することを示した.

さらに関連する動画

Lung Tumor Cell Recruitment Assay
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Lung Tumor Cell Recruitment Assay

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Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

関連する実験動画

Last Updated: Jun 17, 2026

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion
05:23

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Published on: July 7, 2023

Lung Tumor Cell Recruitment Assay
04:28

Lung Tumor Cell Recruitment Assay

Published on: February 26, 2019

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

結論:

  • 循環腫瘍細胞 (CTC) は,その原発腫瘍を植民し,一方的転移モデルに異議を唱える.
  • 攻撃的なCTCと特定の分子因子によって媒介される腫瘍の自己発芽は,腫瘍の進行を高めることができます.
  • このプロセスは,腫瘍の特徴,予後,および完全な切除の後に局所的な再発の間のリンクを明らかにすることができます.