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Updated: May 6, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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Published on: December 7, 2014

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アロステリックをATP結合部位阻害剤と組み合わせることで,Bcr-Ablを標的とする

Jianming Zhang1, Francisco J Adrián, Wolfgang Jahnke

  • 1Dana-Farber Cancer Institute, Harvard Medical School, Department of Cancer Biology, Seeley G. Mudd Building 628, Boston, Massachusetts 02115, USA.

Nature
|January 15, 2010
PubMed
まとめ

研究者らは,Bcr-Ablミリスタート結合部位を標的としたアロステリック阻害剤であるGNF-5を開発した. GNF-5とATP競合薬の組み合わせは抵抗を克服し,Bcr-Abl駆動がんの治療に希望を示しています.

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