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Updated: Jun 17, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

JARID2は,ポリコンブ抑制複合体2の結合をES細胞の標的遺伝子に調節する

Diego Pasini1, Paul A C Cloos, Julian Walfridsson

  • 1Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.

Nature
|January 16, 2010
PubMed
まとめ

JumonjiとARIDドメインを含むタンパク質,JARID2は,ポリコンブ群 (PcG) のタンパク質を標的遺伝子に勧誘するために不可欠です. この募集は,遺伝子抑制,幹細胞の分化,正常な発達に不可欠です.

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...