動脈硬化と心血管疾患:フレミングハム心臓研究
Gary F Mitchell1, Shih-Jen Hwang, Ramachandran S Vasan
1Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA. GaryFMitchell@mindspring.com
Circulation
|January 20, 2010
まとめ
脈波速度 (PWV) で測定されるより高い大動脈の硬さにより,心血管疾患のリスクが著しく増加します. この動脈硬さの測定は,従来の危険因子と組み合わせると,心血管疾患の予測を向上させます.
科学分野:
- 心血管医学 心血管医学
- バイオマーカー バイオマーカー
- エピデミオロジー エピデミオロジー
背景:
- 動脈の硬さと波反射は,心血管リスクマーカーとして提案されています.
- 以前の研究では,硬さ測定の包括的なコミュニティベースの予後評価が欠けていました.
研究 の 目的:
- 地域社会における様々な動脈硬化と波反射の測定と心血管疾患の予後との関係を評価する.
主な方法:
- 割合的な危険モデルでは,フレミングハム心臓研究 (Framingham Heart Study) に参加した2,232人の主要心血管疾患イベントを分析した.
- 評価されたパルス波速度 (PWV),増幅指数,中央パルス圧力,圧力増幅.
- 伝統的な心血管疾患の危険因子に調整されています.
主要な成果:
- 高い大動脈PWVは,最初の心血管疾患のリスクの48%増加と相関していました (P=0.002).
- PWVは,標準的なリスク因子に追加された場合,リスク予測を改善しました (統合された差別改善0.7%,P<0.05).
- 増幅指数,中央パルス圧,圧力増幅は,有意な結果関連性を示さなかった.
結論:
- PWVによって示される大動脈の硬さの増加は,最初の心血管イベントのリスクが高いことと関連しています.
- 大動脈PWVは,コミュニティにおける心血管疾患リスク予測のための貴重なバイオマーカーとして機能します.
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