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Updated: May 3, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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大動脈弁狭窄症の進行：長期レトロスペクティブ研究

S W Davies1, A H Gershlick, R Balcon

  • 1Cardiac Department, London Chest Hospital, U.K.

European heart journal
|January 1, 1991
PubMed

大動脈弁狭窄症は、潜在的に深刻な状態である。軽度から重度の大動脈弁狭窄への進行はよく認識されているが、その進行速度に関するデータは少ない。大動脈弁狭窄症患者65例の臨床転帰および心カテーテル検査データを検討した。各患者は少なくとも2回の心カテーテル検査を受けており、検査間隔は1年から17年（平均7年）であった。60例において大動脈弁圧較差が増加しており、中央値で10 mmHg（範囲 0-60）から52 mmHg（範囲 15-120）へと上昇していた。圧較差の平均増加率は年間6.5 mmHgであり、初回カテーテル検査時に大動脈弁石灰化または大動脈弁閉鎖不全症を認めた患者では、増加速度が有意に速かった（P < 0.02）。本研究は、大動脈弁狭窄の進行が非常に急速である可能性があり、弁の石灰化および逆流と相関することを示している。軽度または中等度の大動脈弁圧較差を有する患者において、併存する冠動脈疾患または僧帽弁疾患に対して心臓手術が検討される場合は、その時点で大動脈弁置換術を検討すべきである。

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