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Updated: Jun 16, 2026

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
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細胞タンパク質のN端アセチル化により,特定の分解信号が生成されます

Cheol-Sang Hwang1, Anna Shemorry, Alexander Varshavsky

  • 1Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

Science (New York, N.Y.)
|January 30, 2010
PubMed
まとめ

タンパク質のN端アセチル化は,真核生物に共通しており,分解のシグナルを与える可能性があります. この研究では,酵母におけるDoa10ユビキチンリガゼによって認識される重要な分解信号 (AcN-デグロン) としてアセチル化されたN端末残基を特定しています.

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