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Updated: Jun 16, 2026

Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models
08:44

Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models

Published on: November 11, 2014

Hsp70はライソソームを安定させ,ニーマン・ピック病に関連したライソソーム病理を逆転させます

Thomas Kirkegaard1, Anke G Roth, Nikolaj H T Petersen

  • 1Apoptosis Department and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark.

Nature
|January 30, 2010
PubMed
まとめ

熱ショックタンパク質70 (Hsp70) は,ビス・モノアシル・グリセロ・フォスファート (BMP) と結合してライソソームを安定させ,酸スフィンゴミエリンゼ (ASM) の活性を増強する. この発見は,リゾソーム貯蔵障害とがんに対する潜在的な新しい治療法を提供します.

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Purification of Hsp104, a Protein Disaggregase07:17

Purification of Hsp104, a Protein Disaggregase

Published on: September 30, 2011

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