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In ovo Expression of MicroRNA in Ventral Chick Midbrain
Published on: September 16, 2013
古代動物のマイクロRNAと組織アイデンティティの進化
Foteini Christodoulou1, Florian Raible, Raju Tomer
1Developmental Biology Unit, European Molecular Biology Laboratory, D-69117 Heidelberg, Germany.
Nature
|February 2, 2010
まとめ
古代のmicroRNAs (miRNAs) は,双子の動物におけるボディプランの複雑さとともに進化した. 初期のmiRNAは,特定の細胞タイプで活性化し,原生体-デウテロストームの祖先の祖先組織を明らかにしました.
科学分野:
- 発達生物学 発達生物学について
- 進化生物学の進化生物学について
- 遺伝学 遺伝学とは
背景:
- 双子動物の進化は,微RNA (miRNA) 数の増加と並行して,複雑性の増大によって特徴付けられています.
- マイクロRNAは,遺伝子調節と発達において重要な役割を果たします.
研究 の 目的:
- 保存された双子のmiRNAファミリーの古代の活動場所を調査する.
- 早期のmiRNAの進化と身体計画の発達との関連を理解する.
主な方法:
- 保存された双方のmiRNA発現パターンの比較分析.
- プラティネリス・ドゥメリリ (原始体),キャピテラ (アネリド),ストロングイロセントロータス (デウテロストーム),ネマトステラ (外群) のmiRNA発現を研究する.
主要な成果:
- 最も古い動物のmiRNA,miR-100および関連するmiRNA (miR-125,let-7) は当初,口の周りの神経分泌細胞で発現していました.
- 他の古代のmiRNAは,運動器の状細胞,脳センター,または主要な臓器系 (CNS,感覚,筋肉,腸) で発見されました.
結論:
- マイクロRNAの進化と組織アイデンティティの確立は,双方向進化の間に密接に結びついていた.
- この研究は,プロトストームとデュテロストームの共通の祖先に存在する最小限の細胞タイプと組織を概説しています.
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