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Updated: Jun 16, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

RAF阻害剤は,MAPK経路を活性化し,成長を促進するために,野生型のRAFを活性化します

Georgia Hatzivassiliou1, Kyung Song, Ivana Yen

  • 1Genentech, South San Francisco, California 94080, USA. hatzivassiliou.georgia@gene.com

Nature
|February 5, 2010
PubMed
まとめ

RAFキナーゼ阻害剤は,がん治療において二重作用を示しています. BRAF変異腫瘍を阻害するが,KRAS変異腫瘍のRAS依存経路を活性化させ,治療戦略に影響を与える.

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Bioluminescence Resonance Energy Transfer (BRET)-Based Assay for Measuring Interactions of CRAF with 14-3-3 Proteins in Live Cells

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