さまざまな冠動脈疾患のリスク因子の修正による予想される寿命増加
J Tsevat1, M C Weinstein, L W Williams
1Department of Medicine, Beth Israel Hospital, Boston, MA.
Circulation
|April 1, 1991
まとめ
冠動脈疾患の危険因子を修正することで,全人口の平均寿命がわずかに伸びます. しかし,特定の危険因子を持つ個人は,禁煙や血圧管理などの標的を絞った介入を通じて,実質的な寿命延長を達成することができます.
科学分野:
- 心血管疾患の研究について
- 公共衛生の介入 公共衛生の介入
- 平均寿命モデリング
背景:
- 冠動脈性心疾患 (CHD) のリスク因子修正は,罹病率と死亡率を減らすことが証明されています.
- これらの改変が平均寿命全体に与える具体的な影響は,まだ十分に理解されていない.
研究 の 目的:
- 米国の人口におけるCHDリスクファクターの修正による潜在的寿命増加を予測する.
- 1990年に35歳になる個人に対する単一のリスク因子変化の影響を分析する.
主な方法:
- 冠動脈疾患政策モデル,状態移行のコンピューターシミュレーションを利用した.
- 1990年,35歳のアメリカ人のコホートに対するモデル化された平均寿命予測.
主要な成果:
- 男性の全人口の増加は,1.1年 (高血圧制御),0.8年 (禁煙),0.7年 (コレステロールの減少),0.6年 (体重減少) である.
- 女性の集団全体の利益:0.8年 (コレステロールの減少),0.7年 (禁煙),0.4年 (血圧制御/体重減少).
- 個人の利益はより顕著である,例えば,禁煙する男性喫煙者は2.3年,コレステロール値が下がる高コレステロールの女性は0.4-6.3年.
結論:
- 単一のリスク因子による修正による全人口の平均寿命の増加は控えめである.
- 特定の危険因子を持つ個人は,ターゲットを絞った介入によって,寿命がより大きく増加することがあります.
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