集団における血圧と血清脂質との関連. トロムソーの研究
1Institute of Community Medicine, University of Tromsø, Norway.
Circulation
|April 1, 1991
まとめ
高血圧は,不健康な血脂プロファイル,特に総コレステロールおよび非HDLコレステロールと関連しています. これらの関連性は,年齢と性別によって異なるため,心臓病のリスクに影響を与える生物学的相互関係を示唆しています.
科学分野:
- 心血管疾患の疫学について
- メタボリックシンドロームの研究
背景:
- 高血圧はアテロゲン性血脂と関連しているが,結果は集団によって異なる.
- 血圧と脂質の関係を理解すると,冠動脈疾患 (CHD) のリスクにおける高血圧の役割が明らかになるかもしれません.
研究 の 目的:
- 血圧と血清脂質レベル (総コレステロール,HDLコレステロール,非HDLコレステロール,トリグリセリド) の間の横断的関連を調べる.
- これらの関係が性別と年齢層によってどのように異なるかを調査する.
主な方法:
- 8,081人の男性 (20~54歳) と7,663人の女性 (20~49歳) の横断分析.
- アントロポメトリックおよびライフスタイル要因を制御した分層分析および多変量法.
- 血清の総コレステロール,HDLコレステロール,非HDLコレステロール,トリグリセリドの評価は,静脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈.
主要な成果:
- 総コレステロールと非HDLコレステロールは,両方の性別で高血圧で有意に増加しました.
- 年齢と性別はコレステロールと血圧の関連性を変化させ,ボディマス指数は有意な調節因子であった.
- トリグリセリドのレベルは血圧とともに上昇し,特に痩せていない人では上昇した; HDLコレステロールは高アルコール消費者の間で正の相関を示した.
結論:
- 血圧と血脂の間には生物学的な相互関係がある.
- これらの相互関係は,高血圧と冠動脈疾患のリスクの増加を結びつけるメカニズムに寄与する可能性があります.
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