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Updated: Apr 16, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

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ヒストン脱酸化酵素Sirt6は,Hif1alpha経由でグルコースホメオスタシスを調節する

Lei Zhong1, Agustina D'Urso, Debra Toiber

  • 1The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.

Cell
|February 10, 2010
PubMed
まとめ

この研究では,SIRT6タンパク質は,グリコリチス遺伝子を調節することによって,グルコースレベルを制御することを明らかにしました. SIRT6欠乏症は低血糖症を引き起こし,グルコースホメオスタシスと代謝疾患の治療に影響を及ぼします.

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