最初の3ヶ月間の胎児の成長制限に関連するリスク要因と結果
Dennis O Mook-Kanamori1, Eric A P Steegers, Paul H Eilers
1The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.
JAMA
|February 11, 2010
まとめ
年齢,血圧,喫煙などの母親の要因は,胎児の早期成長に影響します. 最初の3ヶ月間の成長制限は,早産,低出生体重,および後の成長加速のリスクを高めます.
科学分野:
- 産婦人科と産婦人科を担当しています.
- 胎児の発達について
- 母親の健康について
背景:
- 有害な環境への曝露は胎児の発達適応を誘発する可能性があります.
- 母親の特徴とライフスタイルの影響が,最初の3ヶ月間の胎児の発達と産後の結果に及ぼす影響は,依然として不明確です.
研究 の 目的:
- 最初の3ヶ月間の胎児の成長制限に関連した危険因子を特定するために.
- 最初の3ヶ月間の成長制限の結果を決定する.
主な方法:
- ロッテルダムで1631人の母親を対象とした展望調査 (2001年~2005年).
- 母親の身体的特徴と生活習慣が評価されました.
- 妊娠10~13週間の超音波検査で測定された胎児の冠長 (CRL)
- 出産結果 (早産,低出生体重,妊娠年齢に対して小さい) と産後成長 (2歳まで) との関連が評価されました.
主要な成果:
- 妊産婦の年齢は,最初の3ヶ月間のCRLと正に相関していました.
- ダイアストリック血圧と血圧値の上昇は,CRLの短縮と関連していた.
- 葉酸のサプリメントを摂取しない喫煙と併用した喫煙は,CRLを著しく減少させた.
- 最初の3ヶ月間の成長制限は,早産,低出生体重,および妊娠年齢のために小さいリスクを増やす.
- 減少した最初の3ヶ月間のCRLは,2歳までの産後成長加速を予測しました.
結論:
- 母親の要因は胎児の早期成長に大きな影響を与えます.
- 最初の3ヶ月間の成長制限は,不良な出産結果とそれに続く成長加速の予測要因です.
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