関連する実験動画

Updated: Jun 16, 2026

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis
07:38

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis

Published on: November 3, 2017

血液幹細胞は,新しいタイプの細胞移行によって,大動脈内皮から発生します

Karima Kissa1, Philippe Herbomel

  • 1Institut Pasteur, Unité Macrophages et Développement de l'Immunité and CNRS: URA2578, 25 rue du Dr Roux, F-75724 Paris CEDEX 15, France.

Nature
|February 16, 2010
PubMed
まとめ

血液形成性幹細胞 (HSC) は,斑馬魚の胚の大動脈床から直接発生する. この過程は,内皮の血液形成の移行と呼ばれ,単一の内皮細胞が細胞分裂なしにHSCに変容することを含む.

さらに関連する動画

Generation and Culture of Blood Outgrowth Endothelial Cells from Human Peripheral Blood11:00

Generation and Culture of Blood Outgrowth Endothelial Cells from Human Peripheral Blood

Published on: December 23, 2015

In Vitro Model of Fetal Human Vessel On-chip to Study Developmental Mechanobiology09:12

In Vitro Model of Fetal Human Vessel On-chip to Study Developmental Mechanobiology

Published on: July 28, 2023

関連する概念動画

Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells: