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Updated: Jun 16, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

立体選択的なダイエルス-アルダーサイクル添加を用いて,アリル-アリル相互作用における置換物効果を調査する

Steven E Wheeler1, Anne J McNeil, Peter Müller

  • 1Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.

Journal of the American Chemical Society
|February 18, 2010
PubMed
まとめ

アリル-アリルサンドイッチ複合体の置換効果は,ディエルス-アルダー反応を用いて調査されました. 結果は,pi-systemの寄付ではなく,pi-stackingの相互作用がこれらの効果を駆動し,既存のモデルに挑戦していることを明らかにしています.

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