左心室補助装置による血液動力学的サポートは,故障している人間の心臓の心臓肌細胞DNA含有量を減少させます
Jeremias Wohlschlaeger1, Bodo Levkau, Gero Brockhoff
1Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Hufelandstr 55, 45147 Essen, Germany.
Circulation
|February 18, 2010
まとめ
左心室アシスト装置は,心筋細胞のポリプロイド性を減らし,二倍細胞と二核細胞を増加させます. これは,心不全患者の潜在的な心臓再生と回復を示唆しています.
科学分野:
- 心臓病学 心臓病学
- 細胞生物学 細胞生物学
- 再生医学は,再生医療である.
背景:
- 大人の心肌細胞の再生能力は,怪我後の議論がされています.
- 人間の心不全は,ポリプロイド性心筋細胞を含む.
- 左心室補助装置は,ポリプロイド化メカニズムについての洞察を提供します.
研究 の 目的:
- カーディオミオサイトのDNA含有量,核形態,そして左心房前後核の数を評価するために,アシストデバイスのサポート.
- 心不全における心筋細胞のプロイド性に対する血液動力学的サポートの影響を調査する.
主な方法:
- 23個のペアリングされた心筋膜のサンプルを分析した.
- DNA画像サイトメトリー,フローサイトメトリー,および心筋細胞プロイジーのインサイトハイブリダイゼーション.
- 核面積/周りの形状測定と二核心筋細胞のカウント.
主要な成果:
- カーディオミオサイトDNAの中央値 (6.79cから4.7c) とポリプロイド細胞 (40.2%から23%) の有意な減少.
- 脱荷後の二倍性心筋細胞 (33.4%から50.3%) と二核性心筋細胞 (4.5%から10%) の有意な増加.
- 左心室補助装置のサポート後,心筋細胞のプロイド性および核特性の変化を示した.
結論:
- 減少したポリプロイド性および増加したディプロイド性は,おそらく細胞サイクル進行または幹細胞活動を通じて,二倍性心筋細胞の数値的増加を示唆しています.
- 心臓の再生は,機械的な卸し後に観察された患者の回復と相関することがあります.
- 左心室補助装置のサポートは,心臓肌細胞のプロイディに影響を与え,潜在的な再生反応を示します.
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