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Updated: Jun 16, 2026

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta
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アクティブサイト改造は,SUMO E1のチオエステル結合形成に伴います

Shaun K Olsen1, Allan D Capili, Xuequan Lu

  • 1Structural Biology, Sloan-Kettering Institute, New York, New York 10065, USA.

Nature
|February 19, 2010
PubMed
まとめ

この研究は,SUMOタンパク質のE1酵素活性化背後の構造的メカニズムを明らかにしています. 結晶構造は,E1酵素が触媒ドメインを改造して,重要なチオエステル結合を形成する方法を示しています.

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