関連する実験動画
Updated: Jun 16, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
非メラノーマ性皮膚がんとは
Vishal Madan1, John T Lear, Rolf-Markus Szeimies
1Dermatology Centre, Salford Royal Hospital NHS Foundation Trust, Salford, UK.
Lancet (London, England)
|February 23, 2010
まとめ
非メラノーマ性皮膚がんは増加しています. 研究は,その原因と新しい非侵襲的治療法を探求していますが,予防と治療の有効性は,がんの種類によって異なります.
科学分野:
- 皮膚科 皮膚科について
- 腫瘍学 腫瘍学
- 公衆衛生は公衆衛生である.
背景:
- 非メラノーマ性皮膚がん (NMSCs) の発生率と罹病率の増加は,病原性および治療法に関する研究を必要とする.
- 累積的な日光曝露は,状細胞癌と関連しているが,基礎細胞癌のサブタイプにおけるその役割は不明である.
- NMSCは複雑なゲノタイプ,フェノタイプ,環境要因に起因する.
研究 の 目的:
- NMSCsの病原性を検討する.
- 現在のおよび新興の非侵襲的治療法について議論する.
- 太陽への曝露パターンとNMSCのサブタイプを理解する知識のギャップを強調する.
主な方法:
- 臨床診断は,組織学的検査によって確認された.
- 病変と宿主の特徴に基づいて治療の選択.
- 確立された治療法と実験的な治療法のレビュー.
主要な成果:
- 状細胞癌は,基礎細胞癌とは異なり,前駆体病変から生じる可能性があります.
- ほとんどのNMSCでは,手術による切除が標準です.
- 光ダイナミック療法と局所用イミキモドは,特定の基礎細胞癌のサブタイプのために確立されています.
結論:
- NMSCの病原性を理解することは,効果的な治療法の開発に不可欠です.
- 予防戦略,特に日光曝露に関する戦略は,基礎細胞癌のさらなる検証を必要とします.
- より効果的で組織を節約する治療法については,継続的な研究が必要である.
関連する概念動画
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:19Pigmentation
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
01:14Changes in Skin Color: Clinical Perspectives
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:11Papillary Dermis
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...