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Updated: Jun 15, 2026

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RlmNとCfrは,リボソームRNAのメチル化に関与する SAM酵素である

Feng Yan1, Jacqueline M LaMarre, Rene Röhrich

  • 1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA.

Journal of the American Chemical Society
|February 27, 2010
PubMed
まとめ

この研究では,細菌の酵素RlmNとCfrが,抗生物質耐性における重要なステップであるリボソームRNA (rRNA) をメチレートする方法が明らかにされています. これらのラジカルSAM酵素は,リボソーム組立中に23SrRNAをメチਲੇਟし,薬の有効性に影響を与えます.

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