網膜芽細胞腫のタンパク質のG1/Sリン酸化は,核区間の核系への相性変化と関連しています

S Mittnacht1, R A Weinberg

  • 1Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

Cell
|May 3, 1991
PubMed
まとめ

網膜芽細胞腫タンパク質 (pRB) は,非リン酸化状態で核に強く結合し,成長抑制に不可欠な状態です. ハイパーホスフォリレーションはpRBを放出し,細胞サイクル進行と一致し,ウイルスオンコプロテインの干渉を潜在的に可能にします.

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