頸動脈動脈硬化症を逆転させるための食事介入
Iris Shai1, J David Spence, Dan Schwarzfuchs
1Department of Epidemiology and Health Systems Evaluation, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. irish@bgu.ac.il
Circulation
|March 3, 2010
まとめ
減量ダイエットでは,大動脈動脈硬化,特に大動脈血管壁の体積 (VWV) を逆転させることができます. この回帰は,低脂肪,地中海,低炭水化物ダイエットにおいて一貫しており,主に血圧の低下によって引き起こされます.
科学分野:
- 心血管医学 心血管医学
- 栄養科学とは,栄養科学である.
- メディカルイマージング (医学イメージング)
背景:
- 動脈動脈硬化症を逆転させるためのダイエットによる減量介入の可能性は不明である.
- 動脈動脈硬化症は,心血管疾患の重要なリスク因子です.
研究 の 目的:
- ダイエットによる減量介入が,大動脈動脈硬化症の逆行を誘発できるかどうかを調査する.
- 低脂肪,地中海,低炭水化物ダイエットが頸動脈動脈硬化症の進行に及ぼす影響を比較する.
主な方法:
- 140人の参加者を含む2年間のランダム化対照試験 (DIRECT-Carotid研究)
- 参加者は低脂肪,地中海,または低炭水化物ダイエットに割り当てられました.
- 頸動脈内膜の厚さと頸動脈血管壁の体積 (VWV) は,超音波を用いて測定された.
主要な成果:
- 2年間の食事介入後,大動脈血管壁の平均体積 (VWV) の有意な5%の回帰が観察されました.
- 3つのダイエットグループ間でVWV回帰の有意な差は見つかりませんでした.
- 静脈血圧の低下は,大動脈VWVとインティマ・メディアの厚さ回帰の最も強い独立した予測因子でした.
結論:
- 2年間の減量ダイエットは,測定可能な頸動脈VWVの回帰を効果的に誘導します.
- 観察された回帰は,特定の食事戦略 (低脂肪,地中海,または低炭水化物) に独立しています.
- 体重減少によって引き起こされる血圧の低下は,大動脈動脈硬化症の逆行を促す主なメカニズムです.
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