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Updated: Jun 15, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

サイクロスポリンの全合成:イソニトリル結合反応を通じてN-メチル化ペプチドへのアクセス

Xiangyang Wu1, Jennifer L Stockdill, Ping Wang

  • 1Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.

Journal of the American Chemical Society
|March 5, 2010
PubMed
まとめ

イソニトリルは,効率的なアミド結合形成を可能にし,循環型ポリペプチドであるサイクロスポリンAの合成に不可欠である. この新しい経路は,複雑なアミド合成のために,マイクロ波支援と環境温度のカップリングを使用しています.

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