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Updated: Apr 13, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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腫瘍性ストレス媒介のp53応答におけるトランスクリプション独立のARF調節

Delin Chen1, Jing Shan, Wei-Guo Zhu

  • 1Institute for Cancer Genetics, and Department of Pathology and Cell Biology College of Physicians & Surgeons, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA.

Nature
|March 9, 2010
PubMed
まとめ

腫瘍抑制剤ARFは正常細胞では不安定であるが,がんでは安定している. 新たに特定されたユビキチンリガゼULFは,ARFを分解する標的としており,腫瘍抑制に不可欠な動的ARF-p53経路を明らかにしています.

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