心交感神経刺激による左心室収縮性の増加
Christian Meyer1, Obaida R Rana, Erol Saygili
1Division of Cardiology, RWTH-Aachen University, Aachen, Germany.
Circulation
|March 10, 2010
まとめ
研究者らは,左心室の収縮性を選択的に強化する特定の心臓神経繊維を特定しました. 経静脈カテーテルによるこの選択的刺激は,心拍数上昇などの副作用を回避し,同情的トーンを調節する新しい方法を提供します.
科学分野:
- 心血管生理学 心血管の生理学
- 自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous
- 医療機器技術 医療機器技術について
背景:
- 胸中側交感神経刺激は心臓の収縮性を高めますが,左心室の特異性はなく,望ましくない効果を引き起こします.
- 現在の方法では,左心室内無otropyに対する選択的な制御を提供できません.
研究 の 目的:
- 選択的な左心室内無otropic コントロールのために,心臓内の共感神経構造を特定するために.
- 経静脈カテーテル刺激によるこれらの構造へのアクセスの可能性を評価する.
主な方法:
- 高周波 (200 Hz) 刺激は,冠動脈鼻腔内にある電極カテーテルを使用して,20頭の羊に適用されました.
- 測定には,左心房圧,収縮性指数,心臓出力,超音波ストレイン分析が含まれていました.
- 効果は,心筋耐火期およびβ1受容体阻害後の期間中に評価されました.
主要な成果:
- 心拍数やAV伝導を変化させることなく,選択的に左心室の圧力上昇 (97〜138mmHg) をします.
- 静脈動圧の発達,静脈動脈のリラックス,心拍の出力に顕著な改善が見られました.
- 超音波検査では,左心室のストレスの増加が確認され,効果は4時間持続し,β1-抗原薬によって阻害されました.
結論:
- 左心室を神経化する心臓神経繊維は,経静脈導管電気カテーテル刺激で標的とすることができる.
- このテクニックは,左心室内で特に交感性トーンを直接調節することを可能にします.
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