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Updated: Jun 15, 2026

In Vitro Cleavage Assays using Purified Recombinant Drosophila Caspases for Substrate Screening
08:16

In Vitro Cleavage Assays using Purified Recombinant Drosophila Caspases for Substrate Screening

Published on: October 6, 2022

カスパゼ依存によるディセールリボヌクレアゼの死亡促進性デオキシリボヌクレアゼへの変換

Akihisa Nakagawa1, Yong Shi, Eriko Kage-Nakadai

  • 1Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

Science (New York, N.Y.)
|March 13, 2010
PubMed
まとめ

この研究は,小さなRNA処理に不可欠な酵素であるDicer (DCR-1) が,C. elegans.のアポトーシス中にDNAを断片化することを明らかにしています. カスパーゼ媒介の分裂は,DCR-1をデオキシリボヌクレアースに変換し,DNA分解経路を保存します.

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