メソポラスシリカナノ粒子のサイズ,毛穴の順序,毛穴の整合性の影響が,血解活動に及ぼす影響
Yu-Shen Lin1, Christy L Haynes
1Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA.
Journal of the American Chemical Society
|March 17, 2010
まとめ
毛細なシリカナノ粒子は,サイズに依存する毒性を示すが,毛穴構造が無傷であるときのみである. 毛孔の整合性が損なわれると,血液溶解が増加し,PEGコーティングで除去されます.
科学分野:
- ナノ材料の毒性学について
- シリカナノ粒子の生物互換性について
- 細胞・ナノ粒子相互作用
背景:
- シリカナノ粒子 (SiNPs) は広く使用されており,毒性の評価が必要である.
- ナノ粒子-細胞の相互作用を理解することは,安全なアプリケーションに不可欠です.
- 血液溶解は赤血球膜損傷の重要な指標である.
研究 の 目的:
- 毛穴のあるおよび毛穴のないシリカナノ粒子の毒性を評価するために.
- 毒性に対する毛孔構造と整合性の影響を調査する.
- ナノ粒子誘発血解における表面化学の役割を決定する.
主な方法:
- 赤血球の損傷を測定するための血液溶解測定法.
- 異なるナノ粒子のサイズ,多孔性,表面変化.
- ナノ粒子の構造と毛孔の整合性 (TEM,XRD,N2アドソルプション-デソルプション) の特性.
主要な成果:
- 多孔性および非多孔性SiNPsの両方が,濃度およびサイズに依存する血解を引き起こしました.
- サイズに依存した血液溶解は,オーダーされた毛穴を持つメソポラスなSiNPのみで観察されました.
- 毛穴のあるSiNPは,毛穴のないものよりも低血解活性を示した.
- 毛孔の整合性が損なわれ,血解が増加し,PEGコーティングで除去されました.
結論:
- 孔の構造と整合性は,シリカナノ粒子毒性の重要な要因です.
- 表面化学,特にシラノール基は,溶血活動に影響する.
- PEGによる表面改変は,ナノ粒子によって誘発された血液溶解を軽減することができます.
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