ホメオスタシスと腸の炎症

Wendy S Garrett¹, Jeffrey I Gordon, Laurie H Glimcher

¹Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA. wgarrett@hsph.harvard.edu

Cell

|March 23, 2010

まとめ

腸内微生物群と免疫系との健康的なバランスを維持することは,腸の健康と全体的な健康にとって非常に重要です. 不均衡は,重大な疾患状態につながる可能性があります.

科学分野:

微生物学微生物学とは
免疫学免疫学とは
胃腸内科胃腸内科

背景:

腸は,広大な微生物のコミュニティ,すなわち微生物群を宿している.
免疫系と微生物群の共進化は,宿主-微生物の共生にとって不可欠である.
ディスバイオシス,または不均衡は,宿主の健康に悪影響を及ぼします.

研究の目的:

腸内の炎症反応を調節する細胞および分子メカニズムを見直す.
腸内ホメオスタシスの喪失の結果を探求する.
宿主-微生物群の不均衡から生じる疾患状態を理解するために.

主な方法:

腸内免疫と微生物群に関する既存の文献のレビュー.
炎症に関与する細胞および分子経路の分析.
ディスバイオシスに関連した疾患の病原性の検討.

主要な成果:

炎症反応は,腸内ホメオスタシスを維持するために厳しく調節されます.
宿主と微生物群の間のバランスの喪失は,腸内および全身疾患につながる.
特定の細胞および分子メカニズムは,このバランスの鍵です.

結論:

免疫-微生物群の相互作用によって腸内ホメオスタシスの維持は,健康にとって不可欠です.
ディスバイオシスは,様々な病気の発症の重要な要因です.
これらの規制メカニズムの理解は,治療的な可能性を秘めています.

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