抗炎症剤:現在と未来
1Department of Medicine, University of Colorado, Aurora, 80045, USA. cdinarello@mac.com
Cell
|March 23, 2010
まとめ
慢性的な炎症は,深刻な病気につながる可能性があります. このレビューは,これらの状態を管理するために,生物学的および小分子を含む,現在のおよび開発中の抗炎症薬をカバーしています.
科学分野:
- 免疫学と薬理学について
- 薬物の発見と開発
背景:
- 炎症は正常な免疫反応ですが,慢性炎症は自己免疫疾患,神経変性,がんを誘発します.
- NSAIDのような既存の抗炎症薬は有効ですが,新しい治療戦略が必要です.
研究 の 目的:
- 抗炎症薬の研究の現在の状況を見直す.
- 新規の治療薬とその作用機構を強調する.
主な方法:
- 既存のおよび新興の抗炎症剤に関する文献レビュー.
- 生物学的薬,小分子,スタチン,HDAC阻害剤,PPARアゴニスト,および小RNAを含む薬物クラスの議論.
主要な成果:
- 様々な抗炎症剤が利用可能であり,開発中です.
- 抗キトカイン療法やキナーゼ阻害剤などの新薬クラスは,著しい進歩を表しています.
結論:
- 慢性炎症性疾患の管理には,抗炎症療法に関する継続的な研究が不可欠です.
- 新薬の開発は,より安全で効果的な治療のための有望な経路を提供します.
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