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Updated: Jun 14, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
08:49

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

タンパク質キナーゼC-セータは,T細胞の機能の調節にネガティブなフィードバックを媒介する

Alexandra Zanin-Zhorov1, Yi Ding, Sudha Kumari

  • 1Molecular Pathogenesis Program, Helen and Martin Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

Science (New York, N.Y.)
|March 27, 2010
PubMed
まとめ

タンパク質キナーゼC-セータ (PKC-セータ) は,T細胞 (Treg) 機能の調節を阻害する. PKC-thetaを阻害すると,Tregの活性が強化され,炎症性サイトカインの存在下でTregの機能を回復することで,炎症性疾患の治療の可能性がもたらされます.

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