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Updated: May 11, 2026

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
08:47

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation

Published on: March 5, 2018

カスパース活性化が先行し,タングルにつながります

Alix de Calignon1, Leora M Fox, Rose Pitstick

  • 1MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

Nature
|April 2, 2010
PubMed
まとめ

ニューロフィブリラータングル (NFT) ではなく,カスパースの活性化が,アルツハイマー病のモデルにおけるタウ病理を誘発する. この発見は,タングルではなく,溶解性タウの種が神経変性を誘発し,新しい治療標的を提供することを示唆しています.

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