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エネルギー需要に対するFTO効果と,食品摂取量に対するFTO効果
1Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, Scotland, UK. j.speakman@abdn.ac.uk
Nature
|April 3, 2010
まとめ
FTO遺伝子変異体rs9939609は肥満と関連しています. 人間の研究では,食物の摂取に影響が示唆されているが,FTO欠乏したマウスは代謝率の増加を示し,複雑な肥満メカニズムを示している.
科学分野:
- 遺伝学と肥満の研究
- 代謝調節研究 代謝調節研究
背景:
- 脂肪質量および肥満関連遺伝子 (FTO) の近くにあるintronic single nucleotide polymorphism (SNP) rs9939609は,ボディマス指数 (BMI) と関連している最初の共通変異種である.
- 以前のヒトの研究では,rs9939609が食物の摂取と飽和感の変化と関連しているが,エネルギー消費と一貫していない.
- フィッシャー et al. 最近作成されたFto-無活性化マウス (Fto(-/-)) は,肥満からの保護を示しています.
研究 の 目的:
- 人間の肥満におけるFTO遺伝子とマウスのFto遺伝子機能の対比的なメカニズムを調査する.
- 種間の代謝率と食物摂取の調節におけるFTOの役割を調査する.
主な方法:
- SNP rs9939609に関する既存のヒト遺伝子関連研究とその食物摂取,飽和感,エネルギー消費との関係の分析.
- Fischer et al.による調査結果のレビュー Fto(-/-) のマウスで,野生型の littermatesと比較して,食物摂取と代謝率に焦点を当てました.
主要な成果:
- 人間の研究は,FTO SNP rs9939609を食物の摂取と満腹感の変動と関連付けていますが,エネルギー消費に一貫した影響はありません.
- Fto(-/-) のマウスは,食物の摂取に有意な違いを示さなかったが,代謝率が上昇し,エネルギー消費の増加によって肥満から身を守ることを示唆した.
- マウスでの観察された効果は,FTO SNPのヒト研究で示唆された効果と機械的に正反対の効果である.
結論:
- 人間におけるFTO遺伝子変異とマウスのFto遺伝子機能の対照的な効果は,さらなる調査を必要としています.
- 肥満に対する内部SNP rs9939609の影響には,代謝に影響を与える複雑な種特有の規制メカニズムが含まれている可能性があります.
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