関連する実験動画

Updated: Jun 13, 2026

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids
08:53

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids

Published on: March 21, 2025

アミロイドの自己組織化における核形成と成長の直接観察

Yan Liang1, David G Lynn, Keith M Berland

  • 1The Center for Fundamental and Applied Molecular Evolution and the Center for Chemical Evolution, Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.

Journal of the American Chemical Society
|April 20, 2010
PubMed
まとめ

研究者は,早期アルツハイマー病のアベタペプチド組成を観察し,アミロイドの成長を核化するダイナミックな集積を明らかにしました. この発見は,アミロイド組成を直接観察することによって,タンパク質の誤折り疾患モデルを統一するものである.

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Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

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Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy12:58

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関連する概念動画

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...