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関連する概念動画

Thermosensation01:43

Thermosensation

35.6K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
35.6K
Resting Membrane Potential01:24

Resting Membrane Potential

26.1K
The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
26.1K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

8.2K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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関連する実験動画

Updated: Apr 13, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

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TRPV3でパーマを予防する

Craig Montell1

  • 1Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. cmontell@jhmi.edu

Cell
|April 21, 2010
PubMed
まとめ
この要約は機械生成です。

エピデルマ・成長因子受容体 (EGFR) 信号伝達は,皮膚の健康にとって極めて重要です. 新しい研究によると,カルシウムチャネルTRPV3は,これらのEGFRに依存する皮膚機能に不可欠である.

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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

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Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
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Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

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関連する実験動画

Last Updated: Apr 13, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

10.8K
A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

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Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

8.5K

科学分野:

  • 皮膚科 皮膚科について
  • 細胞生物学 細胞生物学
  • 分子生物学は分子生物学である.

背景:

  • Epidermal成長因子受容体 (EGFR) のシグナル伝達は,皮膚の発達と維持に重要な役割を果たします.
  • 重要な機能には,ケラチノサイトの分化,毛の発達,皮膚の障壁の整合性が含まれます.

研究 の 目的:

  • EGFR依存性皮膚機能におけるトランジント受容体潜在バニロイド3 (TRPV3) チャンネルの役割を調査する.
  • ケラチノサイトにおけるTRPV3とEGFRシグナル伝達経路の関係を解明する.

主な方法:

  • 遺伝子モデルと細胞ベースのアッセイを用いた.
  • EGFRシグナル伝達と下流の細胞プロセスに対するTRPV3の影響を調べました.

主要な成果:

  • TRPV3はEGFRに依存するケラチノサイト末端の分化に欠かせないことを実証しました.
  • TRPV3の適切な髪形変異の要求を示した.
  • EGFRによって調節される皮膚のバリア機能を維持する際にTRPV3の必要性を確認しました.

結論:

  • TRPV3は,表皮におけるEGFRシグナル伝達の重要なメディエーターとして作用します.
  • TRPV3は,皮膚のホメオスタシスと発達に不可欠な複数のEGFR駆動プロセスに不可欠です.