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Updated: May 8, 2026

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
10:56

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Published on: May 17, 2014

タンパク質翻訳の効率を制御するための進化的に保存されたメカニズムです

Tamir Tuller1, Asaf Carmi, Kalin Vestsigian

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.

Cell
|April 21, 2010
PubMed
まとめ

この研究では,メッセンジャーRNA (mRNA) に沿って翻訳効率のプロファイルが保存され,真核生物の遅い開始と速い終了を示しています. このコーディングシーケンス機能は,リボソームの交通渋滞を防ぐことでタンパク質発現を最適化します.

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Improving Translational Accuracy02:07

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Initiation of Translation

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Initiation of Translation

Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
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Translation in Prokaryotes

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Translational Regulation

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