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関連する概念動画

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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関連する実験動画

Updated: Jun 13, 2026

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
03:40

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Published on: December 8, 2023

造血幹細胞移植:グローバルな視点

Alois Gratwohl1, Helen Baldomero, Mahmoud Aljurf

  • 1European Group for Blood andMarrow Transplantation, Transplant Activity Survey Office, Department of Hematology, University Hospital Basel, Basel, Switzerland. hematology@uhbs.ch

JAMA
|April 29, 2010
PubMed
まとめ

血液形成性幹細胞移植 (HSCT) は,世界中の様々な状態のために使用されています. 高所得国,医療費の増加,移植チームが増えることが,高水準のHSCT率の上昇と相関しています.

さらに関連する動画

Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)
20:38

Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)

Published on: February 25, 2007

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

関連する実験動画

Last Updated: Jun 13, 2026

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
03:40

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Published on: December 8, 2023

Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)
20:38

Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)

Published on: February 25, 2007

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

科学分野:

  • 血液学 ヘマトロジ
  • 移植医療 移植医療 移植医療
  • グローバル・ヘルス グローバル・ヘルス

背景:

  • 血液形成性幹細胞移植 (HSCT) は,かなりのリソースを必要とする複雑な手順です.
  • HSCTの利用と影響要因に関する世界的なデータは依然として限られています.

研究 の 目的:

  • 世界中でHSCTの使用を分析する.
  • 異なる地域におけるHSCTの適用における格差を特定する.
  • 世界的にマクロ経済指標とHSCT率の関係を探求する.

主な方法:

  • 2006年に71カ国の1327のセンターを回顧調査したものです.
  • アロゲンおよびオトログのHSCT手順で収集されたデータ.
  • 移植率,徴候,ドナーの種類,マクロ経済要因の分析.

主要な成果:

  • 5万件以上の最初のHSCTが実施され,57%がオトログで43%がオロジェニックでした.
  • HSCTの割合は,地域によって著しく変化し,ヨーロッパが最も高い平均率を示しています.
  • HSCTは,人口が30万人未満,土地面積が小さい,または一人当たりの国民総所得が低い (<680ドル) の国々では実施されなかった.
  • 政府保健費,HSCTチーム密度,人間開発指数,国民一人当たりの総国民所得は,HSCT率と強く関連していました.

結論:

  • 造血幹細胞移植は,世界中で幅広い疾患に適用されています.
  • 健全な医療制度と確立された移植インフラストラクチャを持つ高所得国は,HSCTをより頻繁に利用しています.