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Updated: Jun 13, 2026

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane
07:38

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Published on: March 30, 2015

塩素伝導性よりも,エンドソーマの塩化物-陽子交換が腎臓内分細胞症の決定的な要因である

Gaia Novarino1, Stefanie Weinert, Gesa Rickheit

  • 1Leibniz-Institut für Molekulare Pharmakologie (FMP) and Max-Delbrück-Centrum für Molekulare Medizin (MDC), 13125 Berlin, Germany.

Science (New York, N.Y.)
|May 1, 2010
PubMed
まとめ

エンドソーマアニオントランスポーターClC-5は,腎臓内細胞症とデンツ病の治療に不可欠です. 私たちの研究は,陽子交換だけでなく,エンドソーマル塩化物の上昇が,このプロセスにとって不可欠であることを明らかにしています.

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