運動血圧と将来の心血管疾患による死亡は,無症状の個体において発生する
Sandra A Weiss1, Roger S Blumenthal, A Richey Sharrett
1Brigham and Women's Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA.
Circulation
|May 5, 2010
まとめ
無症状の個体における運動による高血圧 (BP) は,心臓血管疾患 (CVD) による死亡リスクの上昇と関連しています. 具体的には,ブルース2段階のBPが180/90mmHgを超えると,高血圧でない個人がCVDの死亡リスクが増加していることを特定します.
科学分野:
- 心臓病学 心臓病学
- 運動生理学 運動生理学
- 予防医学は,予防的な医療です.
背景:
- 過剰な運動による高血圧 (BP) は,将来の高血圧の予測要因として知られています.
- 運動による高血圧と心血管疾患 (CVD) による死亡率の関連性は依然として議論の余地があります.
研究 の 目的:
- 無症状の個体における運動による高血圧と心血管疾患による死亡率の関連性を調査する.
- 運動によるBPが,特に高血圧でない個体において,心血管疾患による死亡に対する独立した予測値を提供するかどうかを判断する.
主な方法:
- Lipid Research Clinics Prevalence Studyからの6578人の無症状参加者の分析. 脂質研究クリニックの流行調査.
- 20年間の追跡調査で,休息時のBP,運動時のBP (ブルースステージ2および最大) とCVD死亡率の評価が行われました.
- 多変量コックス比例危険性モデルと再分類メトリックを使用した.
主要な成果:
- 休息中のBPがCVD死亡と最も強い関連性を示し,次にブルースステージ2と最大運動BPが続いた.
- 運動BPは,休息BPを調整した後に有意ではなかった.
- しかし,非高血圧患者では,ブルースステージ2BP>180/90mmHgは,他の要因とは関係なく,CVD死亡リスクを大幅に増加させた.
結論:
- 運動による高血圧は心血管疾患による死亡と関連しているが,休息時の血圧を考慮するとその重要性は低下する.
- 180/90 mm Hgを超えるブルースステージ2 BPは,高血圧でない個体におけるCVD死亡リスクの増加の重要な指標です.
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