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Updated: May 17, 2026

Examining the Conformational Dynamics of Membrane Proteins in situ with Site-directed Fluorescence Labeling
11:55

Examining the Conformational Dynamics of Membrane Proteins in situ with Site-directed Fluorescence Labeling

Published on: May 29, 2011

ロングタイムスケールのタンパク質の動きのサンプリング:ホルミル-CoA:オキサラートCoAトランスファーゼにおけるアクティブサイトループコンフォメーション自由エネルギーのOSRWシミュレーション

Sangbae Lee1, Mengen Chen, Wei Yang

  • 1Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA.

Journal of the American Chemical Society
|May 8, 2010
PubMed
まとめ

オートゴナル・スペース・ランダム・ウォーク (OSRW) シミュレーションでは,ホルミル-CoA:オキサラート-CoAトランスファーゼ (FRC) のループ構成がエネルギー的に類似していることを明らかにしています. ミュタゲネーシス研究によると,OSRWは,ループのダイナミクスの変化と酵素効率の低下を予測することができます.

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