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Updated: Jun 13, 2026

Defining Substrate Specificities for Lipase and Phospholipase Candidates
08:59

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Published on: November 23, 2016

アルファ置換エステルの水分解のための広範な基板範囲を持つエナンチオセレクティブリパースの誘導進化

Karin Engström1, Jonas Nyhlén, Anders G Sandström

  • 1Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.

Journal of the American Chemical Society
|May 11, 2010
PubMed
まとめ

誘導的な進化により,Candida antarcticaのリパゼA (CalA) 変種が生まれ,活性が著しく向上し,エステル水解の広範囲な基質範囲を持つようになった. このエンジニアリングされた酵素は,逆の (R) 選択性を示し,新しい合成の可能性を提供します.

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