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Updated: Jun 13, 2026

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
10:31

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

Published on: February 3, 2022

プレペプチド遺伝子置換によるチオシリン変異体の操作:ヘテロサイクルの置換変異体の構造,形状,および活性

Albert A Bowers1, Michael G Acker, Alexander Koglin

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Journal of the American Chemical Society
|May 12, 2010
PubMed
まとめ

バシルス・セレウスATCC 14579は,広範囲にわたる翻訳後の改変によってチオシリン抗生物質を産生する. アラニンとセリンのスキャンにより,トリチアゾリルピリジン核またはマクロサイクリックループの剛性を変更すると,抗生物質の活性が廃止されることが明らかになりました.

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