関連する実験動画
高用量経口ビタミンDの年間投与,高齢女性における転倒と骨折:ランダム化制御試験
Kerrie M Sanders1, Amanda L Stuart, Elizabeth J Williamson
1Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, Victoria, Australia 3220. kerrie@barwonhealth.org.au
JAMA
|May 13, 2010
まとめ
年配の女性に対して毎年高用量のビタミンDを補給すると,転倒や骨折を軽減できず,リスクが増加する可能性があります. この研究では,落下や骨折の予防のためのコレカルシフェロールの単一の年間用量の有効性を調査しました.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- 栄養科学とは,栄養科学である.
- 骨の健康 骨の健康とは
背景:
- ビタミンDの状態は,高齢者の転倒や骨折の修正可能な危険因子です.
- 日々のビタミンDサプリメントの服用は,しばしば不適切である.
- 年間高用量ビタミンDは,代替的なサプリメント戦略を提供することがあります.
研究 の 目的:
- コレカルシフェロールの年間単発投与量50万IUが,高齢女性における粘着性を改善し,転倒や骨折を軽減するかどうかを評価する.
- 高リスク集団における転倒や骨折の発生率に対する高用量ビタミンDの影響を評価する.
主な方法:
- 骨折のリスクが高い70歳以上の女性2,256人を対象とした3~5年間のダブルブラインド・プラセボ対照試験.
- 参加者は毎年50万IUのコレカルシフェロールまたはプラセボを投与された.
- 転倒や骨折は月経カレンダーを通してモニタリングされ,放射線学的に確認され,副研究ではビタミンDレベルが評価されました.
主要な成果:
- コレカルシフェロール群は,プラセボと比較して,転倒 (RR 1.15) と骨折 (RR 1.26) の発生率が高かった.
- 時間のパターンは,投与後3ヶ月以内に転落のリスクが増加したことを示しました.
- ビタミンDの濃度は,サプリメント摂取後に有意に増加したが,転倒や骨折に対する保護効果は与えられなかった.
結論:
- 高用量コレカルシフェロールの年間経口投与は,高齢の女性において,転倒や骨折のリスクを増加させた.
- この補給戦略は,この集団における転倒や骨折の予防に効果的ではないかもしれません.
- 転倒や骨折の予防のための最適なビタミンD用量戦略を決定するために,さらなる研究が必要です.
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