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プライマリケアにおける多発性不安障害に対するエビデンスベースの治療の提供:ランダム化制御試験
Peter Roy-Byrne1, Michelle G Craske, Greer Sullivan
1Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and Harborview Center for Healthcare Improvement for Addictions, Mental Illness, and Medically Vulnerable Populations, Seattle, Washington 98104, USA. roybyrne@u.washington.edu
JAMA
|May 21, 2010
まとめ
調整された不安学習と管理 (CALM) モデルは,通常のケアと比較して,プライマリケアで不安症状と寛解率を大幅に改善しました. この柔軟な治療アプローチは,不安障害のメンタルヘルスの結果を高めます.
科学分野:
- メンタルヘルス研究 メンタルヘルス研究
- プライマリケア介入 プライマリケア介入
- 不安障害の治療法 不安障害の治療法
背景:
- メンタルヘルスの介入を研究から実践に移すことは,医療の質を向上させるために極めて重要です.
- うつ病の治療には進歩があるが,現実の世界での不安障害の研究は限られている.
研究 の 目的:
- プライマリケアにおける一般的な不安障害に対して,柔軟な治療・提供モデルである協調的な不安学習・管理 (CALM) の有効性を評価する.
- 患者のアウトカムを改善するために,CALMモデルと通常のケア (UC) を比較する.
主な方法:
- 17のプライマリケアクリニックで,不安障害の患者1004人を対象としたランダム化制御試験です.
- CALMモデルは,リアルタイムでのアウトカムモニタリングと,ケアマネージャーのためのコンピュータ・アシスタント・サポートで,柔軟な治療オプション (CBT,薬剤,またはその両方) を提供しました.
- 患者は3〜12ヶ月間治療を受け,6,12,18ヶ月でフォローアップ評価を行った.
主要な成果:
- CALMはUCと比較して,6,12,18ヶ月で,全般的な不安症状の改善が著しく示されました.
- 12ヶ月後,CALMはUCよりも高い応答率 (63.7%対44.7%) と寛解率 (51.5%対33.3%) を示しました.
- 応答と寛解のための治療に必要な数は,それぞれ約5.3と5.5でした.
結論:
- CALMモデルは,プライマリケアにおける不安障害の治療において,通常のケアよりも効果的です.
- CALMは,不安やうつ病の症状,機能障害,および18カ月間のケア全体の品質の改善につながります.
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