配列空間とタンパク質宇宙の継続的な膨張
Inna S Povolotskaya1, Fyodor A Kondrashov
1Bioinformatics and Genomics Programme, Centre for Genomic Regulation, Calle Dr Aiguader 88, Barcelona Biomedical Research Park Building, 08003 Barcelona, Spain.
Nature
|May 21, 2010
まとめ
タンパク質の進化は進行中であり,古代のタンパク質は依然として分岐している. 配列分岐の限界は,機能的制約とフィットネス環境から生じ,タンパク質配列の宇宙はまだ完全に探求されていないことを示唆しています.
科学分野:
- 進化生物学の進化生物学について
- バイオケミストリー バイオケミストリー
- 計算生物学とは,計算生物学である.
背景:
- タンパク質の構造的・機能的整合性は,アミノ酸の置換を制限する.
- 同性タンパク質配列の分岐のグローバル限界は不明のままである.
研究 の 目的:
- 配列分岐データを用いてタンパク質進化の限界を探求する.
- 古代のタンパク質の分岐率を調査する.
主な方法:
- タンパク質配列の分岐率を研究するための計算アプローチを策定した.
- 最後の普遍的な共通の祖先に存在するタンパク質の測定された分岐率.
主要な成果:
- 古代のタンパク質は分岐し続けているので,タンパク質配列の宇宙が拡大していることを示している.
- 機能的配列が稀少で,フィットネスの環境が荒れ果てているため,分散は遅い.
- ほとんどのサイトは制限されていますが,補償的な変更により,最終的な進化が可能になります.
結論:
- タンパク質の異なった進化の限界は,35億年後にも達していない.
- ほとんどのタンパク質の配列類似性の限界は,ランダムな配列の限界に近づく可能性があります.
関連する概念動画
01:13Protein Organization
Overview
01:24Protein Organization
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
The primary structure of a protein is its amino acid sequence.
01:13Protein Organization
Overview
01:24Protein Organization
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
The primary structure of a protein is its amino acid sequence.
02:26Conservation of Protein Domains
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
02:26Conservation of Protein Domains Over Different Proteins
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...