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カルシネウリンとATF3の相反する役割は,表皮性皮膚がんにおけるものです

Xunwei Wu1, Bach-Cuc Nguyen, Piotr Dziunycz

  • 1Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA.

Nature
|May 21, 2010
PubMed
まとめ

カルシヌーリンの阻害剤は,状細胞癌 (SCC) のリスクを高めます. カルシヌーリン/NFATシグナル伝達抑制は,ATF3が重要な役割を果たすp53-依存の衰老を阻害することによって,皮膚腫瘍形成を促進します.

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